It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.
Schering did used to make a fast-acting primo, that is, the Methenolone Acetate version as an injectable. However this was 20mg/ml and is no longer made. Some underground labs, particularly in the US have recently been making injectable methenolone acetate. However beware, as there is a reason that it was originally made at 20mg/ml; anything from 50mg/ml and above of this product will cause severe injection site pain following injection, and furthermore pretty much everyone I have read of who has tried this form of Primo at such concentrations will get flu like symptoms after every shot for a day or so. Thus the reason why methenolone acetate is not marketed by any major underground labs.