Exceptions like Cimarron and Rio Rita aside, RKO's product was largely regarded as mediocre, so in October 1931, 29-year-old David O. Selznick visited Sarnoff in New York and convinced him to replace LeBaron as production chief.  As the new studio chief Selznick implemented rigorous cost-control measures, championed the unit production system, which gave the producers of individual movies much greater independence than they had under the prevailing central producer system. "Under the factory system of production you rob the director of his individualism", said Selznick, "and this being a creative industry that is harmful to the quality of the product made" (even though Selznick earned a sour reputation for meddling in director output).  Instituting unit production, he predicted, would also result in cost savings of 30–40 percent.  To make films under the new system, Selznick recruited prize behind-the-camera personnel, such as director George Cukor and producer/director Merian C. Cooper , and gave producer Pandro S. Berman , aged twenty-six, increasingly important projects.  Selznick discovered and signed a young actress who would become a star created by RKO, Katharine Hepburn . Also enlisted was established star John Barrymore for a few memorable performances, when also used by Paramount used as Dr. Jekyll and Mr. Hyde (1920) or Warner Bros. used as Beau Brummel (1924).  From September 1932 on, print advertising for the company's features displayed the revised name "RKO Radio Pictures"; the Pathé name was used only for newsreels and documentaries. [e] That same year, the New York City–based corporate headquarters moved into the new RKO Building , an Art Deco skyscraper above RCA -controlled Radio City Music Hall , which had been one of the first structures in Rockefeller Center to open as part of the complex's construction . 
It should be noted that in theory if one was to consistently suppress your natural estrogen levels for a long period of time, this would negatively impact your health, including your cholesterol. Due to the ability of Letrozole- to inhibit estrogen so much, this should definitely be a concern to most users. However the research that has focused on the relationship between use of letrozole and cholesterol levels is rather inconsistent in it's findings. Many studies have concluded that the compound is detrimental to both a user's HDL and LDL cholesterol levels, while other research has found no link. Obviously individuals are best served to monitor their cholesterol while using any compound via blood tests however barring that, letrozole should simply not be run for extended periods of time if at all possible. Doing so could cause serious medical complications.
Along with the issues related to blood lipids is the fact that many users complain that their libido is dramatically reduced when using the compound. This is related to the fact that estrogen is partly responsible for the regulation of an individual's sex drive. Since Letrozole- is so potent it can often drive estrogen levels too low and this inhibits a user's libido. To avoid this users can lower dosages, but some anecdotally report that even extremely low doses of the drug can cause problems. If this is the case a less potent compound such as exemestane or anastrozole may be a more appropriate option.