Advise both patients and caregivers about the risks of respiratory depression and sedation when ULTRACET is used with benzodiazepines or other CNS depressants (including alcohol and illicit drugs). Advise patients not to drive or operate heavy machinery until the effects of concomitant use of the benzodiazepine or other CNS depressant have been determined. Screen patients for risk of substance use disorders, including opioid abuse and misuse, and warn them of the risk for overdose and death associated with the use of additional CNS depressants including alcohol and illicit drugs [see DRUG INTERACTIONS , PATIENT INFORMATION ].
If you are switching to or from Spironolactone (Aldactone) and Cyprotone Acetate (Androcur) be aware that Androcur is much more powerful as an anti-androgen than Spiro, therfore you don't need to take as much of it. The general rule of thumb for conversion between the two is that Androcur is FOUR TIMES as strong as Spironolactone. So, if you were taking 200mg/day of Spiro that would mean you'd only need 50mg/day of Androcur. It is also suggested that you ramp down off of or up onto Spiro over the course of two to three weeks and start with no more than 25mg/day of Androcur until you are certain you do not have any negative reactions to it. It is important to have your liver function monitored while taking Androcur. Also be aware that people who switch from Spiro to Androcur also often notice a weight gain of between 5 and 20 pounds. Some of it is water weight returning once the diuretic effects of Spiro dissipate.