I heard of MK677 from a young fellow who mentioned he takes it for a short time when he wants to increase his lean mass. He looked liked he did not need it at the time and seemed knowledgeable and I asked what he read to gain his knowledge and said his dad is a doctor an his mom a pharmacist. He said natural growth hormone is active at night. That is why many who take HGH have bad results because taking it during the day disrupts the normal action which affects other hormone paths such as cortisol which is normally most active early in the morning. As it appears MK677 increases action of HGH and iGF-1, and one wants that to peak at night, then it would seem one would want to try MK677 sometime before sleep.