After the Kefauver Harris Amendment was passed in 1962, the . FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol.  In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism .  After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the .
Fed up with muscleheads, Ziegler parted ways with York in 1967. But Dianabol continued to haunt him. Ziegler suffered from heart disease, a condition he partially ascribed to his experimentation with steroids. By the time of his 1983 death from heart failure, Ziegler came out against his invention. "It is bad enough to have to deal with drug addicts, but now healthy athletes are putting themselves in the same category," he wrote in the introduction to Bob Goldman's history of drugs and sports, Death in the Locker Room . "It's a disgrace. Who plays sports for fun anymore?"