After the Kefauver Harris Amendment was passed in 1962, the . FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol.  In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism .  After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the .
Following Dianabol’s rise in popularity, the International Olympic Committee forbade its use in Olympic athletes in 1975; they performed widespread testing for steroids for the first time in 1978. Thus marked the downfall of steroids in the Olympics and in professional sports in the United States. What’s more, in 1998, President Ronald Reagan signed the Drug Abuse Act, which outlawed the recreational use of Dianabol. Finally, the US Congress added it to the list of controlled substances in 1990, and since then, possessing, selling, and using Dianabol is a crime.