Haloperidol drug

Haloperidol is a typical butyrophenone type antipsychotic that exhibits high affinity dopamine D 2 receptor antagonism and slow receptor dissociation kinetics. [42] It has effects similar to the phenothiazines . [17] The drug binds preferentially to D 2 and α 1 receptors at low dose (ED 50 = and  mg/kg, respectively), and 5-HT 2 receptors at a higher dose (ED 50 =  mg/kg). Given that antagonism of D 2 receptors is more beneficial on the positive symptoms of schizophrenia and antagonism of 5-HT 2 receptors on the negative symptoms, this characteristic underlies haloperidol's greater effect on delusions, hallucinations and other manifestations of psychosis. [43] Haloperidol's negligible affinity for histamine H 1 receptors and muscarinic M 1 acetylcholine receptors yields an antipsychotic with a lower incidence of sedation, weight gain, and orthostatic hypotension though having higher rates of treatment emergent extrapyramidal symptoms .

Haloperidol is used to relieve the symptoms of schizophrenia and other problems which affect the way you think, feel or behave. These problems may make you hear, see or sense things that are not there, or believe things that are not true, or feel unusually suspicious. If you are taking haloperidol for these reasons, you may be prescribed tablets or capsules to take for a short while to get your symptoms under control, and then a long-acting, or 'depot', injection may be recommended for you. There is a separate medicine leaflet called Haloperidol long-acting injection which gives more information about this.

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Haloperidol drug

haloperidol drug

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