Valproic acid was first synthesized in 1882 by Beverly S. Burton as an analogue of valeric acid , found naturally in valerian .  Valproic acid is a carboxylic acid , a clear liquid at room temperature. For many decades, its only use was in laboratories as a "metabolically inert" solvent for organic compounds. In 1962, the French researcher Pierre Eymard serendipitously discovered the anticonvulsant properties of valproic acid while using it as a vehicle for a number of other compounds that were being screened for antiseizure activity. He found it prevented pentylenetetrazol -induced convulsions in laboratory rats .  It was approved as an antiepileptic drug in 1967 in France and has become the most widely prescribed antiepileptic drug worldwide.  Valproic acid has also been used for migraine prophylaxis and bipolar disorder. 
Drostanolone propionate and methyl-drostanolone has a mild androgenic and anabolic effects , but in practice it appears to be much stronger androgen compared to papers of value , binds to androgen receptors 3 to 5 times stronger than TST . In its use can be monitored increased muscle hardness and density better , but the weight and strength gains are small . Like other AAS , and drostanoone increases protosyntesis . Does not convert to estrogen , therefore, all flavored , so the emergence of gynecomastia and water retention when there are unknown terms . It is very mild on the liver and its overall side effects are mild . Often brings disappointment to those who still have quite high levels of fat in the body . Its effects tend to manifest precisely in those with low levels of fat . This AAS is even attributed the slight diuretic and fat burning effects . Reduces aldosterone levels , thereby reducing the water level in the body , which is why he attributed to a slight diuretic effect . Of course , like any other derivative of DHT , and drostanolón lowers SHBG in the body , there by increasing the use of free TST in the blood , which in turn increases the anabolic effect of treatments .